Yes, Predator CNC Editor supports an unlimited number of different machines and can communicate with multiple machines. Each machine can have unique COM port, baud rate, and numerous other properties. The Editor supports switchboxes, intelligent switchboxes, and the entire line of Predator DNC and Connect AKA FlexN hardware.
NOTE: The Predator CNC Editor can only communicate to one machine at a time and is not designed for simultaneous multitasking operations to multiple machines. If this is desired, upgrade to Predator DNC, which is designed to support machines simultaneously.