Yes, most DNC Software will work on Windows 10 when specifically designed for modern versions of Microsoft Windows. Most programs are written in 64-bit and backward compatible to work in older 32-bit versions of Microsoft Windows.  Keep in mind, some older versions of DNC Software that were written years ago, do not make full use of the latest computer resources and multi-core processors and can be problematic. If you have used a working DNC Software package in the past under Windows XP, 7 & 8, and experiencing issues, it most likely the application is not compatible with the latest operating system and hardware used to transmit the files to the CNC machines.